A-beta binding polypeptides

US8337845B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• John Park · Warthausen, DE
• Cornelia Dorner-Ciossek · Ingelheim am Rhein, DE
• Stefan Hoerer · Biberach an der Riß, DE
• Lothar Kussmaul · Schemmerhofen, DE
• Martin Lenter · Ulm, DE
• Katharina Zimmermann · Biberach, DE
• Gerald Beste · Evergem, BE
• Toon Laeremans · Dworp, BE
• Pascal MERCHIERS · Kasterlee, BE
• Jo Vercammen · Sint-Pieters-Leeuw, BE

Key dates

• Filing date: Mar 2, 2011
• Grant date: Dec 25, 2012
• Expiry date: Mar 2, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains binding to different epitopes of A-beta. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as Alzheimer's Disease.