4-1BB binding molecules

US8337850B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Bianca Ahrens · Munich, DE
• Sangita M. Baxi · San Diego, US
• Timothy S. Fisher · West Lafayette, US
• Richard Michael Jerome · East Hampstead, US
• Kathrin Ladetzki-Baehs · Planegg, DE
• Theodore Oliphant · Galesburg, US
• Leslie Lynne Sharp · San Diego, US
• Michael Tesar · Heidelberg, DE
• Libbey Anne Yates · Dardenne Prairie, US
• Moritz Zulley · Munich, DE

Key dates

• Filing date: Sep 9, 2011
• Grant date: Dec 25, 2012
• Expiry date: Sep 9, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides isolated binding molecules that bind to human 4-1BB, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.