Method of treating inflammation with glutaminyl cyclase inhibitors

US8338120B2 · kind B2 · utility

Assignee

• PROBIODRUG AG · DE

Inventors

• Stephan Schilling · Halle (Saale), DE
• Holger Cynis · Dohnsen, DE
• Torsten Hoffman · Halle (Saale), DE
• Hans-Ulrich Demuth · Halle (Saale), DE

Key dates

• Filing date: Feb 28, 2008
• Grant date: Dec 25, 2012
• Expiry date: Feb 28, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods for the treatment and/or prevention of an inflammatory disease or disorder through administration of an inhibitor of a glutaminyl peptide cyclotransferase. Inflammatory diseases or disorders treated or prevented by methods disclosed herein include mild cognitive impairment (MCI), rheumatoid arthritis, atherosclerosis, restenosis and pancreatitis.