Systems and methods for delivery of a therapeutic agent
US8338164B2 · kind B2 · utility
51Cited by
51References
21Claims
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Key dates
| Filing date | Oct 5, 2011 |
| Grant date | Dec 25, 2012 |
| Priority date | — |
| Expiry date | Oct 5, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.