Dehydroxy vancomycin, the preparation, pharmaceutical composition and the use
US8338372B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Aug 25, 2008 |
| Grant date | Dec 25, 2012 |
| Priority date | — |
| Expiry date | Sep 30, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/60
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy vancomycin and the use of the said composition in the preparation of drugs for the treatment of susceptible bacteria infections. The method includes the following steps: (1) preparing a concentrated vancomycin solution containing the deshydroxy vancomycin by fermentations of Amycolatopsis Orientalis with Deposit No. CGMCCNO.1183; (2) separating and purifing the concentrated vancomycin solution to obtain a refined filtrate of vancomycin hydrochloride containing the deshydroxy vancomycin by column chromatography; and (3) further separating and purifing the refined filtrate to obtain the deshydroxy vancomycin by chromatography. Wherein, separation and purification is processed by column chromatography in a gel chromatography column containing a salt-water mobile phase, separation and purification is processed by chromatography in a macroporous adsorption resin chromatography column containing a buffer-methanol mobile phase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.