Compounds and compositions as channel activating protease inhibitors

US8338469B2 · kind B2 · utility

Assignee

• IRM Inc. · BM

Inventors

• David C. Tully · San Diego, US
• Amab K. Chatterjee · San Diego, US
• Agnes Vidal · Lemon Grove, US
• Hank Michael James Petrassi · San Diego, US
• Zhiwei Wang · Beijing, CN
• Badry Bursulaya · San Diego, US
• Glen Spraggon · San Diego, US

Key dates

• Filing date: Apr 19, 2011
• Grant date: Dec 25, 2012
• Expiry date: Apr 19, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/0827
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating channel activating proteases, and methods for, using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSS11E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.