Compositions and methods of sensitizing methicillin resistant Staphylococcus aureus to beta-lactam antibiotics

US8338476B2 · kind B2 · utility

Assignees

• Mitsui Norin Co., Ltd. · JP
• The School of Pharmacy, University of London · GB

Inventors

• Paul Stapleton · London, GB
• Yukihiko Hara · Shizuoka, JP
• Peter Taylor · West Haven, US

Key dates

• Filing date: Dec 29, 2005
• Grant date: Dec 25, 2012
• Expiry date: Feb 22, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.