Derivatives of 3,3-diphenylpropylamines

US8338478B2 · kind B2 · utility

Assignee

• UCB Pharma GMBH · DE

Inventors

• Claus Meese · Monheim, DE
• Bengt Sparf

Key dates

• Filing date: Jun 15, 2011
• Grant date: Dec 25, 2012
• Expiry date: Jun 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C307/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns novel derivatives of 3,3-diphenyl-propylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.