Patent · US Active

Macrocyclic compounds for inhibition of tumor necrosis factor alpha

US8338565B2 · kind B2 · utility

1Cited by

20References

4Claims

0Family size

Assignee

Ensemble Therapeutics Corporation · US

Inventors

Jinbo Lee · Andover, US
Julian F. Bond · Weymouth, US
Nicholas K. Terrett · Brookline, US
Frank G. Favaloro · Attleboro, US
Daniel I. C. Wang · Duxbury, US
Timothy F. BRIGGS · Waltham, US
Benjamin A. Seigal · Watertown, US
Wei-Chuan Sun · Menlo Park, US
Stephen Hale · Belmont, US

Key dates

Filing date	Aug 20, 2009
Grant date	Dec 25, 2012
Priority date	—
Expiry date	Nov 26, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D257/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.