Compounds having a potentiating effect on the activity of ethionamide and uses thereof

US8338599B2 · kind B2 · utility

Assignees

• INSTITUT PASTEUR DE LILLE · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• Universite de Lille 2, Universite du Droit et de la Sante · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

• Benoit Deprez · Lille, FR
• Nicolas Willand · Lille, FR
• Bertrand Dirie · Marcq-en-Barœul, FR
• Patrick Toto · Lille, FR
• Vincent Villeret · Wannebecq, BE
• Camille Locht · Wannehain, FR
• Alain Baulard · Templeuve, BE

Key dates

• Filing date: Jul 4, 2007
• Grant date: Dec 25, 2012
• Expiry date: Jun 30, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to the use of compounds with a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, for the preparation of a medicament for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to pharmaceutical compositions comprising them in combination with an antibiotic that is activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics that are activatable via the EthA enzymatic pathway, to pharmaceutical compositions comprising them and to their use as medicaments, especially medicaments for preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.