Methods for humanizing antibodies and humanized antibodies made thereby
US8343489B2 · kind B2 · utility
7Cited by
0References
18Claims
0Family size
Inventors
Key dates
| Filing date | Mar 21, 2007 |
| Grant date | Jan 1, 2013 |
| Priority date | — |
| Expiry date | Feb 11, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/567
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein is the use of three-dimensional structure information to guide the process of modifying antibodies with amino acids from one or more templates or surrogates such that the antigen binding properties of the parent antibody are maintained and the immunogenicity potential is reduced when administered as a therapeutic in humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.