Protective proteins of S. agalactiae, combinations thereof and methods of using the same

US8343510B2 · kind B2 · utility

Assignee

• Intercell AG · AT

Inventors

• Beatrice Senn · Wien, AT
• Eszter Nagy · Wien, AT
• Andreas Meinke · Pressbaum, AT
• Alexander Von Gabain · Wien, AT
• Barbara Maierhofer · Niederabsdorf, AT
• Ulrike Stierschneider · Wien, AT
• Manfred Berger · Wiener Neustadt, AT
• Christina Neubauer · Wiener Neustadt, AT
• Katherine Cohen · Wien, AT

Key dates

• Filing date: Jan 10, 2008
• Grant date: Jan 1, 2013
• Expiry date: Jan 6, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.