Patent · US Active

Monomethylvaline compounds having phenylalanine side-chain replacements at the C-terminus

US8343928B2 · kind B2 · utility

38Cited by

62References

26Claims

0Family size

Assignee

SEATTLE GENETICS, INC. · US

Inventors

Svetlana O. Doronina · Snohomish, US
Toni Kline · Seattle, US

Key dates

Filing date	Jul 7, 2006
Grant date	Jan 1, 2013
Priority date	—
Expiry date	Dec 6, 2029

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) are provided having C-terminal phenylalanine residue side chain replacements or modifications which are provided alone or attached to ligands through various linkers. The related conjugates can target specific cell types to provide therapeutic benefit.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.