Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification
US8343991B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Feb 13, 2008 |
| Grant date | Jan 1, 2013 |
| Priority date | — |
| Expiry date | Aug 11, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to anhydrous crystalline vinflunine salts obtained with 1 or 2 equivalents of a pharmaceutically acceptable mineral or organic acid [Acid] 1 or 2 in which [Acid] represents hydrobromic, sulfuric, lactic and fumaric acids for the group of water-soluble crystalline salts, and para-toluene sulfonic, benzoic, mandelic and para-hydroxy benzoic acids for the group of relatively insoluble crystalline salts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.