Water-soluble polymer-based cantharimides as potentially selective anti-tumor agents

US8344007B2 · kind B2 · utility

Assignee

• The Hong Kong Polytechnic University · CN

Inventors

• Johnny Cheuk-on Tang · Hong Kong, CN
• Albert Sun-Chi Chan · Kowloon, CN
• Kim-hung Lam · Hong Kong, CN
• Chung-hin Chui · Hong Kong, CN
• Stanton Hon-Lung Kok · Sha Tin, CN
• Marcus Chun Wah Yuen · Kowloon, CN
• Sau Hing Chan · Hong Kong, CN
• Chor Hing Cheng · Hong Kong, CN
• Filly Cheung · Hong Kong, CN

Key dates

• Filing date: Apr 23, 2009
• Grant date: Jan 1, 2013
• Expiry date: Oct 26, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A cantharimide compound may include the backbone of formula (1). R1, R2, R3, and R4 may be independently selected from the group consisting of H, C(O)OR5, C(O)R6, C(O)NR7R8, NR9C(O)R10, N—R11R12, O—R13, S—R14, P(O)(OR15)(OR16), As(O)(OR17)(OR18), SO2R19, SO3R20, and B(OR21). X1 to X4 may be independently selected from the group consisting of nitrogen and carbon, such that X1 to X4 are not all hydrogen. Y1, Y2 and R5 to R21 may be independently selected from the group consisting of hydrogen, C1-12-alkyl, -aryl, heteroaryl, and a bioactive polymer.