Patent · US Active

Process for preparing crystalline polymorphic forms of (6R)-L-erythro-tetrahydrobiopterin dihydrochloride

US8344139B2 · kind B2 · utility

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3References

19Claims

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Assignee

Merck Eprova AG · CH

Inventors

Rudolf Moser · Schaffhausen, CH
Viola Groehn · Dachsen, CH
Thomas Egger · Illnau, CH
Fritz Blatter · Reinach, CH

Key dates

Filing date	May 10, 2010
Grant date	Jan 1, 2013
Priority date	—
Expiry date	May 10, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Crystal forms of (6R)-L-erythro-tetrahydrobiopterin dihydrochloride, hydrates and solvates and processes for their preparation are provided. These crystal forms are either intermediates for the preparation of stable polymorphic form B or are suitable for solid formulations.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.