Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof

US8349308B2 · kind B2 · utility

Assignee

• Mersana Therapeutics, Inc. · US

Inventors

• Aleksandr V. Yurkovetskiy · Littleton, US
• Mao Yin · Needham, US
• Timothy B. Lowinger · Carlisle, US
• Carolina B. Cabral · Somerville, US
• Charles E. Hammond · Billerica, US
• Cheri A. Stevenson · Haverhill, US

Key dates

• Filing date: Mar 28, 2011
• Grant date: Jan 8, 2013
• Expiry date: Jun 29, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2320/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polynucleotide delivery vehicle comprising a modified polymer is provided herein, the modified polymer having the following formula:in which W1, W2, W3, W4, W5, W6, Z1, Z2, Z3, Z4, Z5, Z9, R1, R2, R3, R4, R5, n1, n2, n3, n4, n5, and n6 are defined herein. Also disclosed are methods of delivering a polynucleotide to the cytoplasm of a selected tissue type or cell type and methods of reducing expression of a gene in a cell or a subject in need thereof with the modified polymer.