Method for controlling perfusion of an organ

US8349551B2 · kind B2 · utility

Assignee

• LIFELINE SCIENTIFIC, INC. · US

Inventors

• Donald R. Owen · New Orleans, US
• David Kravitz · Chicago, US
• John Brassil · Northbrook, US
• Kelvin G. M. Brockbank · Charleston, US
• Andrew Burroughs · Kenosha, US
• Dickon Isaacs · Chicago, US
• Dennis Steibel, JR. · Lake Zurich, US
• Richard Fraser · Bartlett, US
• Stanley Harris · Fairfax, US
• Douglas Schein · Des Plaines, US

Key dates

• Filing date: Nov 5, 2010
• Grant date: Jan 8, 2013
• Expiry date: Nov 5, 2030

Classification

• Technology area (CPC H): Electricity
• CPC primary: H04L67/02
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.