Heterobicyclic sphingosine 1-phosphate analogs

US8349849B2 · kind B2 · utility

Assignee

• BIOGEN IDEC MA INC. · US

Inventors

• Richard D. Caldwell · Melrose, US
• Kevin M. Guckian · Northborough, US
• Gnanasambandam Kumaravel · Westford, US
• Wen-Cherng Lee · Lexington, US
• Edward Yin-Shiang Lin · Ashland, US
• Xiaogao Liu · Dover, US
• Bin Ma · Arlington, US
• Daniel Scott · Weston, US
• Zhan Shi · Concord, US
• Jermaine Thomas · Chelsea, US
• Arthur G. Taveras · Rockaway, US
• Guo Zhu Zheng · Lexington, US

Key dates

• Filing date: Oct 30, 2009
• Grant date: Jan 8, 2013
• Expiry date: Aug 14, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I):that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.