Bicyclic compounds for the reduction of beta-amyloid production

US8349880B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Lawrence R. Marcin · Bethany, US
• Lorin A. Thompson, III · Higganum, US
• Kenneth M. Boy · Durham, US
• Jason M. Guernon · Hamden, US
• Mendi A. Higgins · Meriden, US
• Jianliang Shi · Furlong, US
• Yong-Jin Wu · Madison, US
• Yunhui Zhang · Glastonbury, US
• John E. Macor · Guilford, US

Key dates

• Filing date: Jan 7, 2010
• Grant date: Jan 8, 2013
• Expiry date: Nov 12, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides a series of compounds of the formula (I)which reduce β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.