Method for the stereoselective synthesis of phosphorus compounds

US8350022B2 · kind B2 · utility

Assignee

• Universitaet Hamburg · DE

Inventors

• Chris Meier · Jork, DE
• Jens O. Thomann · Emstek, DE

Key dates

• Filing date: Apr 3, 2009
• Grant date: Jan 8, 2013
• Expiry date: Jan 19, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for stereoselective synthesis of phosphorus compounds, whereby in the first reaction step a chiral auxiliary on the phosphorus atom of phosphoryl chloride, thiophosphoryl chloride or phosphorus trichloride is covalently bonded, the product from the first reaction step is reacted in the following step with an alcohol, thiol, or amine as the nucleophile in the presence of a base, and in the last step the chiral auxiliary is displaced from the product of the following step by a nucleophile.