Substituted isoquinoline derivatives, pharmaceutical compositions, and methods of use as beta-secretase inhibitors

US8350039B2 · kind B2 · utility

Assignee

• High Point Pharmaceuticals, LLC · US

Inventors

• Adnan M. M. Mjalli · Oak Ridge, US
• Bapu Gaddam · Ellicott City, US
• Devi Reddy Gohimukkula · Jamestown, US
• Dharma Rao Polisetti · High Point, US
• Hassan El Abdellaoui · Jamestown, US
• Mohan Rao · Greensboro, US
• Pingzhen Wang · Kernersville, US
• Robert Carl Andrews · Jamestown, US
• Rongyuan Xie · Greensboro, US
• Tan Ren · High Point, US

Key dates

• Filing date: Aug 22, 2011
• Grant date: Jan 8, 2013
• Expiry date: Aug 22, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to substituted isoquinoline derivatives, pharmaceutically acceptable salts thereof, and tautomers of such compounds or salts, that inhibit β-site amyloid precursor protein-cleaving enzyme (BACE) and that may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which BACE is involved.