Fluorescent xanthenes and white light fluorophores

US8350064B2 · kind B2 · utility

Assignee

• BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE · US

Inventors

• Robert M. Strongin · Baton Rouge, US
• Isiah M. Warner · Baton Rouge, US
• Youjun Yang · Mian County, CN
• Mark Allen Lowry · Portland, US
• Sayo O. Fakayode · Waco, US
• Jorge O. Escobedo Cordova · Portland, US
• Xiangyang Xu · Nanhu, CN

Key dates

• Filing date: Jul 19, 2007
• Grant date: Jan 8, 2013
• Expiry date: Jun 5, 2029

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N1/30
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexing” techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges.