5,6-dimethyl xanthone-4-acetic acid derivatives and method of preparing the same

US8350065B2 · kind B2 · utility

Assignee

• GRANDPHARMA (CHINA) CO., LTD. · CN

Inventors

• Wei Li · Laishui, CN
• Guofan Xie · 红钢城街道, CN
• Jianzhong Zhou · Zhenjiang, CN
• Bo Yang · Zhejiang, CN
• Zhiqiang Qian · 红钢城街道, CN
• Yan Chen · 红钢城街道, CN
• Haiming Geng · 红钢城街道, CN
• Jianming Zhou · Suzhou, CN
• Lu Huang · Riverdale, US

Key dates

• Filing date: Oct 19, 2009
• Grant date: Jan 8, 2013
• Expiry date: Jul 16, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of preparation of 5,6-dimethylxanthone-4-acetic acid (DMXAA) and derivatives thereof. The derivatives are represented by formula (I), wherein R represents totally 1 to 2 substitutes at 1, 2, 3, 7, and 8 position selected from a lower alkyl, halogen, CF3, CN, NO2, NH2, CH2COOH, OR2, OH, NHSO2R2, SR2, CH2CONHR2 or NHR2, and R2 represents a lower alkyl, or a lower alkyl having OH, NH2, or OCH3. The invention further provides a pharmaceutical composition having such derivatives used as excellent antitumor and antibacterial agents.