Multivariate optical elements for nonlinear calibration
US8352205B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 25, 2008 |
| Grant date | Jan 8, 2013 |
| Priority date | — |
| Expiry date | Sep 3, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/12769
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present subject matter is direct to methodologies for calibrating data obtained from an optical analysis system. An initial calibration matrix of sampled analyte concentrations is modified using mean-centering techniques and selection of low and high analyte concentration spectra to produce a two-point calibration. A modified calibration matrix is produced by generating a non-linear calibration matrix by multiplying the initial calibration matrix by the two-point calibration. In an alternate embodiment, an initial multivariate optical element design is modified by iteratively adjusting the design based on standard error of calibration determination based on non-linerly fitted functions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.