Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry

US8354092B2 · kind B2 · utility

Assignee

• Siemens Medical Solutions USA, Inc. · US

Inventors

• Hartmuth C. Kolb · El Segundo, US
• Joseph C. Walsh · Santa Monica, US
• Dhanalakshmi Kasi · Los Angeles, US
• Vani P. Mocharla · Los Angeles, US
• Bing Wang · San Jose, US
• Umesh B. Gangadharmath · Los Angeles, US
• Brian A. Duclos · Kalamazoo, US
• Kai Chen · Rockville, US
• Wei Zhang · San Diego, US
• Gang Chen · Sammamish, US
• Henry Clifton Padgett · Hermosa Beach, US
• Farhad Karimi · Mansfield, US
• Peter J. H. Scott · Ypsilanti, US
• Zhiyong Gao · Los Angeles, US
• Qianwa Liang · La Puente, US
• Thomas Lee Collier · Perkasie, US
• Tieming Zhao · Los Angeles, US
• Chunfang Xia · Los Angeles, US

Key dates

• Filing date: Aug 25, 2010
• Grant date: Jan 15, 2013
• Expiry date: Nov 25, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.