Patent · US Active

Neurotransmitter sensors and methods of using the same

US8354250B2 · kind B2 · utility

0Cited by

6References

28Claims

0Family size

Assignee

Carnegie Institution of Washington · US

Inventors

Sakiko Okumoto · Washington, US
Loren Looger · Sterling, US
Wolf B. Frommer · Washington, US

Key dates

Filing date	Jun 25, 2010
Grant date	Jan 15, 2013
Priority date	—
Expiry date	Aug 25, 2030

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/00
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Neurotransmitter biosensors are disclosed, including YbeJ-based glutamate binding biosensors, comprising a neurotransmitter binding domain conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon binding neurotransmitter. Such biosensors are useful for the detection of neurotransmitter concentrations in vivo and in culture.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.