Methods and compositions for delivering siRNA into mammalian cells

US8354387B2 · kind B2 · utility

Assignee

• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR

Inventors

• Gilles Divita · Mauguio, FR
• May Catherine Morris · Mauguio, FR
• Frederic Heitz · Grabels, FR
• Federica Simeoni · Montpellier, FR

Key dates

• Filing date: Feb 23, 2009
• Grant date: Jan 15, 2013
• Expiry date: Jan 5, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/64
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Complex comprising a peptide carrier of SEQ ID NO:1 GALFLGFLGAAGSTMGAWSQPKR1KRKVR2 and an appropriate siRNA, wherein R1 represents any amino acid residue and more preferably K or S, R2 is null or represents one of the following groups: cysteamide, cysteine, thiol, amide, linear or ramified C1-C6 alkyl optionally substituted, primary or secondary amine, osidic derivative, lipid, phospholipid or cholesterol and said siRNA is selected to silence a target mRNA.