Quinolin-4-one and 4-oxodihydrocinnoline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP)

US8354413B2 · kind B2 · utility

Assignee

• Istituto di Recerche di Biologia Molecolare P. Angeletti S.R.L. · IT

Inventors

• Philip Jones · Houston, US
• Olaf Kinzel · Heidelberg, DE
• Uwe Koch · Roma, IT
• Jesus Maria Ontoria Ontoria · Pomezia, IT
• Giovanna Pescatore · Cosenza, IT
• Rita Scarpelli · Pomezia, IT
• Caterina Torrisi · Roma, IT

Key dates

• Filing date: Aug 21, 2008
• Grant date: Jan 15, 2013
• Expiry date: Aug 22, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.