Monohydrochloride salt of 1-[3-[3-(4-chlorophenyl) propoxy]propyl]-piperidine

US8354430B2 · kind B2 · utility

Assignee

• BIOPROJET · FR

Inventors

• Manuel Raga · Barcelona, ES
• Juan Sallares · Sant Cugat del Vallès, ES
• Marta Guerrero · Barcelona, ES
• Antonio Guglietta · Molins de Rei, ES
• Jean-Michel Arrang · Gif-sur-Yvette, FR
• Jean-Charles Schwartz · Paris, FR
• Holger Stark · Bad Homburg vor der Höhe, DE
• Walter Schunack · Berlin, DE
• Xavier Ligneau · Brive-la-Gaillarde, FR
• Jeanne-Marie Lecomte · Paris, FR
• Charon Ganellin · Thame, GB

Key dates

• Filing date: Jun 7, 2012
• Grant date: Jan 15, 2013
• Expiry date: Jun 7, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method is provided for the treatment of sleep apnea and other conditions wherein an effective amount of crystalline 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine monohydrochloride of formula (I):optionally comprising water up to 6%, and having an X-ray diffractogram that comprises characteristic peaks (2θ) at 11.2°, 19.9°, 20.7° and 34.1°±0.2° is administered to a patient in need thereof.