Process for obtaining a concentrate of Von Willebrand factor or a complex of factor VII/Von Willebrand factor and use of the same

US8354505B2 · kind B2 · utility

Assignee

• GRIFOLS, S.A. · ES

Inventors

• Pere Ristol Debart · Sabadell, ES
• Maria Mercedes Faro Tomas · Parets del Vallès, ES
• Juan Ignacio Jorquera Nieto · Venta de Baños, ES

Key dates

• Filing date: Jan 7, 2009
• Grant date: Jan 15, 2013
• Expiry date: May 1, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A concentrate of Von Willebrand Factor (VWF) or a complex of Factor VIII/VWF is prepared by creating a solution of VWF or a complex of Factor VIII/VWF containing VWF at a concentration of up to 12 IU VWF:RCo/ml and a VWF/Factor VIII ratio of 0.4 or more; and nanofiltering that starting solution through a filter of pore size of 35 nanometers or smaller. The resulting VWF retains high molecular weight multimers.