Patent · US Active

Antibodies for the selective determination of procalcitonin 1-116

US8354506B2 · kind B2 · utility

20Cited by

1References

4Claims

0Family size

Assignee

B.R.A.H.M.S GMBH · DE

Inventors

Andreas Bergmann · Berlin, DE
Joachim Struck · Berlin, DE

Key dates

Filing date	Feb 21, 2008
Grant date	Jan 15, 2013
Priority date	—
Expiry date	Oct 24, 2028

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/585
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention provides an immunodiagnostic method for determining procalcitonin and procalcitonin derivatives in a biological sample of a patient for diagnostic purposes, in particular in the monitoring and control of treatment and the monitoring of the progression of a local or systemic bacterial infection, inflammation, sepsis or neurodegenerative disease. In particular, the method detects molecular forms of procalcitonin, or procalcitonin partial peptides derived therefrom, having the amino acids alanine and proline (Ala-Pro, AP) in positions 1 and 2 of the amino terminus of the complete procalcitonin 1-116 (SEQ ID NO: 1.) Also disclosed are antibodies and kits for carrying out such a method.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.