Patent · US Active

Antibodies to human programmed death receptor PD-1

US8354509B2 · kind B2 · utility

381Cited by

15References

11Claims

0Family size

Assignee

MSD OSS B.V. · NL

Inventors

Gregory J. Carven · Maynard, US
Hans Van Eenennaam · Oss, NL
Gradus Johannes Dulos · Elst, NL

Key dates

Filing date	Jun 13, 2008
Grant date	Jan 15, 2013
Priority date	—
Expiry date	Jun 13, 2028

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/52
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Antibodies which block the binding of human Programmed Death Receptor 1 (hPD-1) to its ligands (hPD-L1 or hPD-L2) and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune response through the PD-I pathway is also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.