Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors

US8354526B2 · kind B2 · utility

Assignee

• IRM Inc. · BM

Inventors

• Qiang Ding · San Diego, US
• Yahua Liu · San Diego, US
• Xu Wu · San Diego, US
• Qihui Jin · San Diego, US
• Jianwei Che · San Diego, US
• S. Frank Yan · Shanghai, CN

Key dates

• Filing date: Jan 27, 2009
• Grant date: Jan 15, 2013
• Expiry date: Mar 5, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof.