Patent · US Active

Environmentally stable sensors and methods of using the same

US8357505B2 · kind B2 · utility

1Cited by

9References

20Claims

0Family size

Assignee

Carnegie Institution of Washington · US

Inventors

Wolf B. Frommer · Washington, US
Loren Looger · Sterling, US

Key dates

Filing date	Oct 14, 2005
Grant date	Jan 22, 2013
Priority date	—
Expiry date	Jul 6, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/60
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Environmentally stable biosensors are disclosed, which comprise a ligand binding domain from a thermophilic organism conjugated to donor and fluorescent moieties that permit detection and measurement of Fluorescence Resonance Energy Transfer upon ligand binding. Such biosensors demonstrate enhanced acid-, thermal- and chemical stability as compared to sensors constructed using protein domains from mesophilic organisms.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.