Method of identifying improved conjugates of biologically active compounds

US8357506B2 · kind B2 · utility

Inventors

• Michael Burnet · Bingen, DE
• Jan-Hinrich Guse · Asperg, DE
• Gene Kim · Bingen, DE
• Albert Beck · Nehren, DE
• Georgia Tsotsou · Lörrach, DE
• Irina Droste-Borel · Tübingen, DE
• Laurence Barker · Bingen, DE
• Michael Wolff · Monheim, DE
• Hans-Jurgen Gutke · Stuttgart, DE

Key dates

• Filing date: Jun 12, 2008
• Grant date: Jan 22, 2013
• Expiry date: Jul 21, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/5094
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.