Gamma secretase modulators

US8357682B2 · kind B2 · utility

Inventors

• Zhaoning Zhu · Plainsboro, US
• William J. Greenlee · Teaneck, US
• Zhong-Yue Sun · Sayreville, US
• Gioconda V. Gallo · Summit, US
• Theodros Asberom · West Orange, US
• Xianhai Huang · Hackettstown, US
• Xiaohong Zhu · Edison, US
• Mark D. McBriar · Clinton, US
• Dmitri Pissarnitski · Scotch Plains, US
• Zhiqiang Zhao · Scotch Plains, US
• Ruo Xu · Watchung, US
• Hongmei Li · Hackettstown, US
• Anandan Palani · Bound Brook, US
• Johannes H. Voigt · Cranford, US
• Robert Mazzola · Stewartsville, US
• John W. Clader · Cranford, US
• Hubert Josien · Hoboken, US
• Jun Qin · Edison, US

Key dates

• Filing date: May 5, 2008
• Grant date: Jan 22, 2013
• Expiry date: Feb 8, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides a novel class of heterocyclic compounds of Formula (I) as modulators of gamma secretase, wherein the definitions of the variables of Formula (I) are defined herein, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.