Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds

US8357694B2 · kind B2 · utility

Assignee

• ArQule Inc. · US

Inventors

• Syed Ali · North Andover, US
• Mark A. Ashwell · Carlisle, US
• Manish Tandon · Framingham, US
• Nivedita Namdev · Westford, US
• Jean-Marc Lapierre · Pelham, US
• Neil Westlund · Groton, US
• Rocio Palma · North Andover, US
• Rui-Yang Yang · Lexington, US
• Yanbin Liu · Acton, US
• David Vensel · Brookline, US
• Sudharshan Eathiraj · North Andover, US
• Hui Wu · Malden, US
• Eugene Kelleher · Somerville, US

Key dates

• Filing date: Dec 30, 2009
• Grant date: Jan 22, 2013
• Expiry date: Jan 1, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.