Spiro group-containing amide compounds having bradykinin 1 receptor (B1R) activity

US8357717B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Stefan Schunk · Aachen, DE
• Melanie Reich · Aachen, DE
• Michael Engels · Turnhout, BE
• Tieno Germann · Aachen, DE
• Ruth Jostock · Stolberg, DE
• Sabine Hees · Aachen, DE

Key dates

• Filing date: Feb 5, 2010
• Grant date: Jan 22, 2013
• Expiry date: Feb 5, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted spiroamide compounds corresponding to formula (I):wherein A, B, Q1, Q2, Q3, Q4, R1, R8, R9a, R9b, R12, R13, R200 and R210 have defined meanings, processes for their preparation, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting pain or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).