Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
US8357807B2 · kind B2 · utility
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15References
22Claims
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Key dates
| Filing date | May 1, 2008 |
| Grant date | Jan 22, 2013 |
| Priority date | — |
| Expiry date | Apr 28, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D217/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.