Tablet formulations containing 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one salts and tablets made therefrom

US8361500B2 · kind B2 · utility

Assignee

• OPKO Health, Inc. · US

Inventors

• Zhihui Qiu · Bound Brook, US
• Wing-Kee Philip Cho · Princeton, US
• Na Zhao · Beijing, CN
• Victor Ming-She Wong · Hackettstown, US

Key dates

• Filing date: Mar 20, 2008
• Grant date: Jan 29, 2013
• Expiry date: Jul 22, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical formulations containing a salt of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I, which are suitable for forming into a tablet dosage form, as well as tablet dosage forms are disclosed. Disclosed also are methods of treatment utilizing such dosage forms.