Nucleoside and nucleotide analogues with quaternary carbon centers and methods of use
US8361988B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 17, 2008 |
| Grant date | Jan 29, 2013 |
| Priority date | — |
| Expiry date | Jul 28, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention comprises compounds useful as antiviral or antitumor agents. The compounds comprise nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moeities with quaternary centers at the 3′ position. The nucleotide analogues can be used to inhibit cancer or viruses. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting diseases or conditions associated with cancers and viruses. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit viruses or tumors and treat, prevent, or inhibit the foregoing diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.