Patent · US Active

Compounds and their use as IKACh blockers

US8361998B2 · kind B2 · utility

1Cited by

1References

7Claims

0Family size

Assignee

ASTRAZENECA AB · SE

Inventors

Jonas Bostrom · Timrå, SE
Hans Emtenas · Mölndal, SE
Kenneth Granberg · Mölndal, SE
Mickael Mogemark · Mölndal, SE
Antonio Llinas · Timrå, SE

Key dates

Filing date	Nov 29, 2011
Grant date	Jan 29, 2013
Priority date	—
Expiry date	Nov 29, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D211/62
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to compounds according to Formula I:or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, x and y are as defined herein. Compounds according to Formula I are pharmacologically effective as potassium channel inhibitors, in particular inhibitors of the acetylcholine operated inward rectifying potassium channel current (i.e. IKACh blockers), and are believed to be useful in the treatment of cardiac arrhythmias, in particular supraventricular tacharrhythmias, such as atrial fibrillation and atrial flutter.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.