4-phenylpiperidine derivatives as renin inhibitors

US8362040B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Richard Sedrani · Basel, CH
• Juergen Klaus Maibaum · Basel, CH
• Werner Breitenstein · Basel, CH
• Holger Sellner · Buchs, CH
• Claus Ehrhardt · Lörrach, DE
• Nils Ostermann · Binzen, DE

Key dates

• Filing date: May 28, 2010
• Grant date: Jan 29, 2013
• Expiry date: Dec 24, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the present invention having the formulaexhibit inhibitory activity on the natural enzyme renin. Thus, compounds of formula (I) may be employed for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.