Pharmaceutical compositions with improved dissolution
US8362062B2 · kind B2 · utility
2Cited by
112References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 24, 2003 |
| Grant date | Jan 29, 2013 |
| Priority date | — |
| Expiry date | Apr 22, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D231/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to methods of screening mixtures containing a pharmaceutical compound and an excipient to identify properties of the pharmaceutical compound/excipient combination that retard solid-state nucleation. The invention further relates to increasing the solubility, dissolution and bioavailability of a drug with low solubility in gastric fluids conditions by combining the drug with a precipitation retardant and an optional enhancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.