Peptides targeting TNF family receptors and antagonizing TNF action, compositions, methods and uses thereof
US8362218B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 16, 2010 |
| Grant date | Jan 29, 2013 |
| Priority date | — |
| Expiry date | Aug 25, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides modulators of TNF, particularly peptides and their derivatives, particularly GEP peptides, which antagonize TNF and TNF-mediated responses, activity or signaling. The invention provides methods of antagonizing TNF and the modulation of TNF-mediated diseases or responses, including inflammatory diseases and conditions. Compositions of GEP peptides, including in combination with other inflammatory mediators, are provided. Methods of treatment, alleviation, or prevention of TNF-mediated diseases and inflammatory conditions, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, inflammatory bowel diseases, Chrohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.