Benzophenone thiazole derivatives useful for inhibiting formation of microtubule and method for producing the same
US8362267B2 · kind B2 · utility
2Cited by
1References
6Claims
0Family size
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Key dates
| Filing date | Mar 5, 2009 |
| Grant date | Jan 29, 2013 |
| Priority date | — |
| Expiry date | May 9, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are a novel thiazole-containing benzophenone derivative represented by formula 1, and an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof and a solvate thereof, a pharmaceutical composition comprising the derivative, a use of the derivative as therapeutic agent and a method for preparing the derivative. The benzophenone thiazole derivatives inhibit formation of microtubules and eliminate actively proliferating cells of malignant tumors to control general cell proliferation. In formula 1, R, R1 and R2 are defined as above.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.