Compounds for the diagnosis of diseases associated with VCAM expression

US8367039B2 · kind B2 · utility

Assignee

• GUERBET · FR

Inventors

• Marc Port · Deuil-la-Barre, FR
• Olivier Rousseaux · Senlis, FR
• Robert Muller · Potsdam, DE
• Carmen Burtea · Mons, BE

Key dates

• Filing date: Mar 28, 2008
• Grant date: Feb 5, 2013
• Expiry date: May 30, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of the following general formula (I): Signal-Linker-Peptide (I) in which Signal is a signal entity; Linker, is absent or is a chemical bond, and Peptide is a peptide having a VCAM-targeting peptide and pharmaceutically acceptable salts thereof. The VCAM-targeting peptide may be X10-X11-X12-X13-X14-X15-X16-X17-X18 (SEQ ID No. 4) with X10 chosen from cysteine and methionine; X11 chosen from methionine and cysteine; X12 chosen from lysine, arginine and alanine; X13 chosen from threonine and serine; X14 chosen from aspartic acid and glutamic acid; X15 chosen from threonine and serine; X16 chosen from arginine, alanine and lysine; X17 chosen from leucine, isoleucine and valine; X18 chosen from cysteine and methionine; preferably, the peptide CMKTDTRLC (SEQ ID No. 5).