Method for bacteriophage delivery and amplification

US8367058B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary of Agriculture · US
• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US

Inventors

• Billy Hargis · Fayetteville, US
• Stacy E. Higgins · Fayetteville, US
• Lisa Bielke · Wooster, US
• Guillermo Tellez · Fayetteville, US
• Lisa A. Newberry · Bentonville, US
• Gerardo Nava · Urbana, US
• Ann M. Donoghue · Springdale, US
• Daniel Donoghue · Oregon, US

Key dates

• Filing date: Apr 21, 2011
• Grant date: Feb 5, 2013
• Expiry date: Apr 21, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2795/10232
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected by the methods. Also disclosed are methods of treating a subject infected with a pathogenic bacterium using bacteriophage and methods of decontaminating objects using bacteriophage. Also disclosed are methods of producing vaccines. In another aspect, methods of determining bacterial viability and methods of improving the sensitivity of a biosensor using wide host range bacteriophages are disclosed.