Patent · US Active

Immunogenic lipopeptides comprising T-helper and B-cell epitopes

US8367067B2 · kind B2 · utility

5Cited by

3References

13Claims

0Family size

Assignee

The Council of the Queensland Institute of Medical Research · AU

Inventors

David Charles Jackson · Elmore, AU
Weiguang Zeng · Sydney, AU

Key dates

Filing date	Jun 19, 2009
Grant date	Feb 5, 2013
Priority date	—
Expiry date	May 17, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K2039/6068
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.